N,N,N',N'-Tetramethylazodicarboxamide → Methyl heptanoate

HRID 394397ノート

反応式

HRID 394397 の反応式
[CH3:1][O:2][C:3](=[O:19])[CH:4](CC1C=CC(O)=CC=1C)[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C1(C(C2SC(C3C=CC(C(F)(F)F)=CC=3)=NC=2C)O)CC1.C(P(CCCC)CCCC)CCC.CN(C)C(N=NC(N(C)C)=O)=O>>[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

5

反応物 4

HCID 4278N,N,N',N'-TetramethylazodicarboxamideHCID 13831TributylphosphineHCID 22647406[Rac]-cyclopropyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanolHCID 68617926[Rac]-2-(4-hydroxy-2-methyl-benzyl)-heptanoic acid methyl ester

生成物 1

HCID 7826Methyl heptanoate

実験手順

In analogy to the procedure described in example 10 c], [rac]-2-(4-hydroxy-2-methyl-benzyl)-heptanoic acid methyl ester (example 126 c]) was reacted with [rac]-cyclopropyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol (example 121 a]) in the presence of tributylphosphine and N,N,N′,N′-tetramethyl azodicarboxamide to yield 2-(4-cyclopropyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methoxy}-2-methyl-benzyl)-heptanoic acid methyl ester as a mixture of two diastereomeric racemates as yellow oil.

出典と根拠

ORDレコード
ord-b6df97f636284b40a39f7898a90a6987
出典データセット
uspto-grants-2004_10
特許番号
US06809110B2

反応ノート

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