Sodium Hydroxide → [Rac]-2-(2-methyl-4-{1-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-benzyl)-butyric acid

反応式

C([O:3][C:4](=[O:36])[CH:5]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]([CH3:34])([C:18]2[S:22][C:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)=[N:20][C:19]=2[CH3:33])[CH3:17])=[CH:11][C:10]=1[CH3:35])[CH2:6][CH3:7])C.[OH-].[Na+]>>[CH3:35][C:10]1[CH:11]=[C:12]([O:15][C:16]([CH3:17])([C:18]2[S:22][C:21]([C:23]3[CH:24]=[CH:25][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:28]=3)=[N:20][C:19]=2[CH3:33])[CH3:34])[CH:13]=[CH:14][C:9]=1[CH2:8][CH:5]([CH2:6][CH3:7])[C:4]([OH:36])=[O:3]

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 68617029[Rac]-2-(2-methyl-4-{1-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-benzyl)-butyric acid ethyl ester

生成物 1

HCID 22647447[Rac]-2-(2-methyl-4-{1-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-benzyl)-butyric acid

実験手順

In analogy to the procedure described in example 10 d], [rac]-2-(2-methyl-4-{1-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-benzyl)-butyric acid ethyl ester was treated with 3 N NaOH to obtain [rac]-2-(2-methyl-4-{1-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-benzyl)-butyric acid as colorless liquid.

後処理

customdescribed in example 10 d

出典と根拠

ORDレコード: ord-953503b3e76944ff8007f744310eee58
出典データセット: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06809110B2

反応ノート

読み込み中…