Syringaldehyde → HCID 54431732、化合物

HRID 394423

反応式

HRID 394423 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:12][CH3:13])[C:10]=1[OH:11])[CH:6]=O.[C:14]([O:20][CH2:21][CH3:22])(=[O:19])[CH2:15][C:16]([CH3:18])=[O:17].N1(CC(O)=O)CCCCC1>C1C=CC=CC=1>[CH2:21]([O:20][C:14](=[O:19])[C:15]([C:16](=[O:17])[CH3:18])=[CH:6][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[C:10]([OH:11])=[C:9]([O:12][CH3:13])[CH:8]=1)[CH3:22]

参加物

5

反応物 3

HCID 8655SyringaldehydeHCID 8868Ethyl AcetoacetateHCID 201097Piperidin-1-yl-acetic acid

生成物 1

HCID 54431732HCID 54431732、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Monodemethylation of 3,4,5-trimethoxy benzaldehyde using sulphuric acid at 40° C. for 8 hours as described above in Example 1 yields syringaldehyde. Condensation of 3,5-Dimethoxy-4-hydroxy benzaldehyde (syringaldehyde) with ethyl acetoacetate in the presence of piperidine—acetic acid and benzene as the reaction medium at reflux temperature yields the title product. The reaction takes about 3.5 hours for completion.

後処理

  1. temperatureat reflux temperature

出典と根拠

ORDレコード
ord-602d9d1954fa44eb829423fbca755f27
出典データセット
uspto-grants-2003_08
特許番号
US06602515B2

関連ノート

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