2-Bromoanisole → 2-Chloro-5-(2-methoxybenzoyl)pyridine

HRID 39448

反応式

HRID 39448 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[Li]CCCC.[Cl:15][C:16]1[CH:27]=[CH:26][C:19]([C:20](N(OC)C)=[O:21])=[CH:18][N:17]=1>C1COCC1>[Cl:15][C:16]1[N:17]=[CH:18][C:19]([C:20]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[O:8][CH3:9])=[O:21])=[CH:26][CH:27]=1

参加物

5

反応物 3

HCID 113582-BromoanisoleHCID 114355976-Chloro-N-methoxy-N-methylnicotinamideHCID 178418339Butyllithium

生成物 1

HCID 202271802-Chloro-5-(2-methoxybenzoyl)pyridine収率 50.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 1-bromo-2-methoxy-benzene (49.2 g, 0.263 mol) in dry THF (500 mL) was added dropwise n-BuLi (2.5 M in hexane, 105 mL, 0.263 mol) at −78° C. under N2 atmosphere. The mixture was stirred at this temperature for 1 hr and then a solution of 6-chloro-N-methoxy-N-methyl-nicotinamide (50 g, 0.25 mol) in THF (100 mL) was added dropwise. The reaction mixture was warmed to room temperature, stirred overnight and then was quenched with a saturated solution of NH4Cl (300 mL). The separated aqueous layer was extracted with ethyl acetate (3×300 mL). The combined organic layers were washed with brine, dried over Na2SO4, evaporated in vacuo to give the crude product that was purified by column chromatography to yield (6-chloropyridin-3-yl)-(2-methoxyphenyl)-methanone as a white solid (31 g, 47.6%).

後処理

  1. stirringstirred overnight
  2. customwas quenched with a saturated solution of NH4Cl (300 mL)
  3. extractionThe separated aqueous layer was extracted with ethyl acetate (3×300 mL)
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over Na2SO4
  6. customevaporated in vacuo
  7. customto give the crude product that
  8. customwas purified by column chromatography

出典と根拠

ORDレコード
ord-2c21bb9dbe0248cb809478b18ccda685
出典データセット
uspto-grants-2013_09
特許番号
US08524910B2

関連ノート

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