Trifluoroacetic acid → 6-Bromo-1,2,3,4-tetrahydro-3-quinolinamine

HRID 394553ノート

反応式

HRID 394553 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH:6]([NH:12]C(=O)OC(C)(C)C)[CH2:5]2.FC(F)(F)C(O)=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH:6]([NH2:12])[CH2:5]2

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 17758659tert-Butyl (6-bromo-1,2,3,4-tetrahydroquinolin-3-yl)carbamate

生成物 1

HCID 181770896-Bromo-1,2,3,4-tetrahydro-3-quinolinamine収率 220.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (6-Bromo-1,2,3,4-tetrahydro-3-quinolinyl)carbamic acid, 1,1-dimethylethyl ester (652 mg, 2 mmol) in dichloromethane at RT under argon was added trifluoroacetic acid (1 mL). After 3 hours, the mixture was concentrated. Chloroform (10 mL) was added and concentrated again in vacuo to afford the title compound (1 g), an oil, which was used without further purification. MS; M(+H)+=227.

後処理

  1. concentrationthe mixture was concentrated
  2. additionChloroform (10 mL) was added
  3. concentrationconcentrated again in vacuo

出典と根拠

ORDレコード
ord-877a6170d33b49108b4aa99b093cd8b4
出典データセット
uspto-grants-2003_08
特許番号
US06602883B1

反応ノート

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