2-(3,4-Dihydro-2H-4-chromenylidene)acetonitrile → 2-(Chroman-4-yl)acetonitrile

HRID 394667

反応式

HRID 394667 の反応式
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[CH:11][C:12]#[N:13])[CH2:3][CH2:2]1>C(O)C.[Pd]>[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([CH2:11][C:12]#[N:13])[CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 569848342-(3,4-Dihydro-2H-4-chromenylidene)acetonitrile

生成物 1

HCID 133627812-(Chroman-4-yl)acetonitrile

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The unsaturated compound obtained in Step A (Z+E mixture), solubilised in ethanol (20 ml), is introduced into the reactor of a Parr apparatus. 10% (by weight) palladium-on-carbon is then added. The double bond is hydrogenated at a pressure of 45 psi for 12 hours. The catalyst is removed by filtration; the solvent is then evaporated. The residual oil is purified on a silica column eluted by a mixture of AcOEt/PE 3/7. Colourless oil.

後処理

  1. customThe catalyst is removed by filtration
  2. customthe solvent is then evaporated
  3. customThe residual oil is purified on a silica column
  4. washeluted by a mixture of AcOEt/PE 3/7

出典と根拠

ORDレコード
ord-5e8b3bae9636410ab4676fbaad6cae90
出典データセット
uspto-grants-2003_08
特許番号
US06602903B2

関連ノート

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