Allylamine → HCID 4153372、化合物

HRID 395236ノート

反応式

HRID 395236 の反応式
[C:1](Cl)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH2:9]([NH2:12])[CH:10]=[CH2:11]>O1CCCC1>[CH2:9]([NH:12][C:1](=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[CH:10]=[CH2:11]

参加物

4

反応物 2

HCID 7853AllylamineHCID 67340Hexanoyl chloride

生成物 1

HCID 4153372HCID 4153372、化合物収率 95.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
15 °C

実験手順

Hexanoyl chloride (33 g, 0.25 mol) in 250 mL of tetrahydrofuran was added to a three neck round bottom flask equipped with a thermometer, stir bar, and dropping funnel. The contents of the flask were then cooled to 15° C. in an ice bath while stirring. Allylamine (28.6 g 0.5 mol) in 200 mL of tetrahydrofuran was then added slowly through the dropping funnel while maintaining stirring. Throughout the addition, the temperature was maintained at 15° C. After addition was complete, stirring continued for an additional 15 minutes, after which the solid allylamine chloride precipitate was filtered off. The filtration was concentrated under vacuum to yield 37 g of N-allyl hexanamide as a colorless viscous liquid.

後処理

  1. customequipped with a thermometer
  2. stirringwhile stirring
  3. temperaturewhile maintaining
  4. stirringstirring
  5. additionThroughout the addition
  6. temperaturethe temperature was maintained at 15° C
  7. additionAfter addition
  8. stirringstirring
  9. filtrationafter which the solid allylamine chloride precipitate was filtered off
  10. filtrationThe filtration
  11. concentrationwas concentrated under vacuum

出典と根拠

ORDレコード
ord-d2ef61e5f5434733959ebae7490fc8d4
出典データセット
uspto-grants-2003_08
特許番号
US06605270B1

反応ノート

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