反応式
C[O:2][C:3](=[O:10])[CH2:4][CH:5]([O:8][CH3:9])[O:6][CH3:7].O[Li:12].O.O>C1COCC1>[Li+:12].[CH3:7][O:6][CH:5]([O:8][CH3:9])[CH2:4][C:3]([O-:10])=[O:2]参加物
5
実験手順
(Related to methods described in Alabaster, C. T. et. al., J. Med. Chem. 1988, 31, 2048-2056.) 3,3-Dimethoxypropanoic acid methyl ester (14.25 g, 96.2 mmol) in THF (100 mL) was treated with LiOH H2O (2.5 g, 106 mmol) and H2O (2 mL). The mixture was brought to reflux for 4 hours, cooled to room temperature and azeotropically dried from THF (4 times) to provide white solids (13.3 g).
後処理
- temperatureto reflux for 4 hours
- dry with materialazeotropically dried from THF (4 times)
出典と根拠
- ORDレコード
- ord-e18510a797e744ae90bed1c13013668e
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06605610B1
関連ノート
読み込み中…