Phenylmethylsulfonyl Fluoride → Potassium alpha-toluenesulfonate

HRID 3956

反応式

HRID 3956 の反応式
[C:1]1([CH2:7][S:8](F)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[Si](C)(C)[O-:14].[K+:17]>O1CCCC1>[C:1]1([CH2:7][S:8]([O-:10])(=[O:14])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[K+:17]

参加物

4

反応物 2

HCID 4784Phenylmethylsulfonyl FluorideHCID 23668039Potassium trimethylsilanolate

生成物 1

HCID 23666503Potassium alpha-toluenesulfonate収率 58.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

The procedure of Example 1 was followed using α-toluenesulfonyl fluoride (2.0 g, 11.5 mmol) in dry tetrahydrofuran (15 mL), potassium trimethylsilanolate (1.48 g, 11.5 mmol) and dry tetrahydrofuran (45 mL), and 2 h of heating at reflux. Potassium α-toluenesulfonate (1.41 g, 58% yield) was isolated as a white solid: 1H NMR (D2O) δ 4.1 (s, CH2, 2H), 7.4 ppm (s, Ar--H's, 5H).

後処理

  1. temperatureof heating
  2. temperatureat reflux

出典と根拠

ORDレコード
ord-38f5d19da7814e449f56363466a7475c
出典データセット
uspto-grants-1988_02
特許番号
US04723016

関連ノート

読み込み中…