O-Methylhydroxylamine → N-Benzyloxy-3-(2-chloro-4-iodo-phenylamino)-isonicotinamide

HRID 39577

反応式

HRID 39577 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH3:19][O:20][NH2:21]>>[CH2:19]([O:20][NH:21][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][N:17]=[CH:18][C:10]=1[NH:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[Cl:1])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 4113O-MethylhydroxylamineHCID 576496513-[(2-Chloro-4-iodophenyl)amino]isonicotinic acid2 回

生成物 1

HCID 11677348N-Benzyloxy-3-(2-chloro-4-iodo-phenylamino)-isonicotinamide

実験手順

N-Benzyloxy-3-(2-chloro-4-iodo-phenylamino)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.25 mmol of 3-[(2-chloro-4-iodophenyl)amino]isonicotinic acid (intermediate 2) and 0.36 mmol of O-methyl-hydroxylamine. LC/MS [10.01 min; 480 (M+1)]

後処理

  1. customLC/MS [10.01 min; 480 (M+1)]

出典と根拠

ORDレコード
ord-1df105a36f79423b8282b7920231b394
出典データセット
uspto-grants-2013_09
特許番号
US08524911B2

関連ノート

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