Acetyl chloride → Ethanone, 1-(4-octylphenyl)-

HRID 395940

反応式

HRID 395940 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[CH2:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[C:19](Cl)(=[O:21])[CH3:20]>ClC(Cl)C>[CH2:5]([C:13]1[CH:14]=[CH:15][C:16]([C:19](=[O:21])[CH3:20])=[CH:17][CH:18]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 16607OctylbenzeneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 66344Ethanone, 1-(4-octylphenyl)-

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

Aluminum chloride (22.6 g) is suspended in dichloroethane (500 ml) and octylbenzene (16) (21.5 g) is added at room temperature. To the mixture is added acetyl chloride (8.87 g) under ice-cooling. The mixture is stirred at room temperature overnight. The reaction mixture is poured into ice water and extracted with ether. The organic layer is washed with brine and dried over sodium sulfate. The solvent is evaporated to give 4′-octylacetophenone (18′) as a colorless oil.

後処理

  1. temperaturecooling
  2. extractionextracted with ether
  3. washThe organic layer is washed with brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is evaporated

出典と根拠

ORDレコード
ord-f0335febdb6e4fc9a41e2e6dafd45797
出典データセット
uspto-grants-2003_08
特許番号
US06605744B2

関連ノート

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