Bromine → 2-(Benzyloxy)-5-(2-oxiranyl)benzamide

HRID 395967ノート

反応式

HRID 395967 の反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:8]([CH:12]=1)[C:9]([NH2:11])=[O:10])(=[O:3])[CH3:2].BrBr>C(Cl)(Cl)Cl>[CH2:14]([O:13][C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][O:3]2)=[CH:12][C:8]=1[C:9]([NH2:11])=[O:10])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 24408Bromine4 回HCID 30186095-Acetyl-2-(phenylmethoxy)benzamide

生成物 1

HCID 99035062-(Benzyloxy)-5-(2-oxiranyl)benzamide収率 87.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

5-Acetyl-2-(phenylmethoxy)benzamide (10.0 g, 37.1 mmol) was dissolved in chloroform and brought to reflux. Bromine (1.98 g, 12.4 mmol) was added. The solution was allowed to cool to room temperature. After 10 minutes the bromine color had disappeared and a second portion of bromine was added. A third portion of bromine was added after the color had again discharged and the solution refluxed for a further 10 minutes. The flask was allowed to cool and placed in the freezer overnight. The solvent was removed in vacuo and the residue crystallized from ethanol to provide the title compound (11.3 g, 32.4 mmol).

後処理

  1. temperatureto reflux
  2. temperaturethe solution refluxed for a further 10 minutes
  3. temperatureto cool
  4. customplaced in the freezer overnight
  5. customThe solvent was removed in vacuo
  6. customthe residue crystallized from ethanol

出典と根拠

ORDレコード
ord-8adb6f6b6868499690162f52b9f915f3
出典データセット
uspto-grants-2003_08
特許番号
US06605618B2

反応ノート

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