Ethanol → (S)-N-(4-(Oxiran-2-ylmethoxy)phenyl)methanesulfonamide

HRID 395971ノート

反応式

HRID 395971 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=1)[C:2]1C=CC=C[CH:3]=1.[H][H].C([OH:24])C>[Pd]>[O:24]1[CH2:3][C@H:2]1[CH2:1][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 702EthanolHCID 669037N-(4-phenylmethoxyphenyl)methanesulfonamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 11322479(S)-N-(4-(Oxiran-2-ylmethoxy)phenyl)methanesulfonamide

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

N-[4-(Benzyloxy)phenyl]methanesulfonamide (3.0 g, 10.8 mmol) was dissolved in ethanol (150 mL). 10% Palladium on carbon (0.3 g) was added and the mixture shaken overnight under 50 psi hydrogen on a Parr apparatus. The solution was filtered through a Celite pad and the solvent removed to yield the title compound (1.32 g, 7.4 mmol).

後処理

  1. filtrationThe solution was filtered through a Celite pad
  2. customthe solvent removed

出典と根拠

ORDレコード
ord-5bb2412e5b044c4884b6d40a5fede0a0
出典データセット
uspto-grants-2003_08
特許番号
US06605618B2

反応ノート

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