Methanol → Methyl 10,12-pentacosadiynoate

HRID 396102

反応式

HRID 396102 の反応式
[C:1]([OH:27])(=[O:26])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]#[C:11][C:12]#[C:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25].[CH3:28]O>S(=O)(=O)(O)O.C(Cl)(Cl)Cl>[C:1]([O:27][CH3:28])(=[O:26])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]#[C:11][C:12]#[C:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

参加物

5

反応物 2

HCID 887MethanolHCID 53843310,12-Pentacosadiynoic acid

生成物 1

HCID 145561Methyl 10,12-pentacosadiynoate

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 6212Chloroform溶媒

実験手順

10,12-pentacosadiynoic acid (10 gm, GFS Chemicals) was dissolved in a solution containing 10 ml methanol (HPLC grade) and 10 ml chloroform (HPLC grade). The solution was stirred at room temperature and 10 drops of neat sulfuric acid was added drop wise. The solution was warmed to 100° F. for 2 hour. The reaction mixture was purified using column chromatography. The product (MePDA) was dried using a rotovap and the material stored in a chloroform solution. The solid form of MePDA was very unstable to polymerization and therefore kept dissolved in organic solutions.

後処理

  1. temperatureThe solution was warmed to 100° F. for 2 hour
  2. customThe reaction mixture was purified
  3. dry with materialThe product (MePDA) was dried
  4. customThe solid form of MePDA was very unstable to polymerization
  5. dissolutionkept dissolved in organic solutions

出典と根拠

ORDレコード
ord-b2453d96b47543b990fbad02313c1a9d
出典データセット
uspto-grants-2003_08
特許番号
US06607744B1

関連ノート

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