1-[5-(Benzyloxy)-2-nitrophenyl]-2-methyl-2-propen-1-one → 1-(2-Amino-5-hydroxyphenyl)-2-methyl-1-propanone
反応式
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:20]([O-])=O)=[C:13]([C:15](=[O:19])[C:16]([CH3:18])=[CH2:17])[CH:14]=1)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:20][C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][C:13]=1[C:15](=[O:19])[CH:16]([CH3:17])[CH3:18]参加物
4
実験手順
0.2 g of palladium/carbon (10%) is suspended in a solution of 1.34 g (4.51 mmol) of 1-[5-(benzyloxy)-2-nitrophenyl]-2-methyl-2-propen-1-one in 50 ml of ethanol. The mixture is shaken under a hydrogen atmosphere at 3 bar for 4.5 h, then the mixture is filtered off through kieselguhr, the filtrate is concentrated in vacuo and the residue is purified on silica gel (cyclohexane/ethyl acetate 5:2-1:1). 511 mg (63%) of 1-(2-amino-5-hydroxyphenyl)-2-methyl-1-propanone are obtained.
後処理
- filtrationthe mixture is filtered off through kieselguhr
- concentrationthe filtrate is concentrated in vacuo
- customthe residue is purified on silica gel (cyclohexane/ethyl acetate 5:2-1:1)
出典と根拠
- ORDレコード
- ord-170ae0dc62884323981a076ca699acae
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06608049B2
反応ノート
読み込み中…