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Diisopropylethylamine → 1,1-Dimethylethyl 2-{[6-(2,4-dichlorophenyl)-5-nitropyrazin-2-yl]amino}ethylcarbamate

HRID 396166
ノート
印刷プレビュー

反応式

HRID 396166 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:10]([N+:16]([O-:18])=[O:17])=[N:11][CH:12]=[C:13](Br)[N:14]=1.[C:19]([NH:26][CH2:27][CH2:28][NH2:29])([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].CCN(C(C)C)C(C)C>CN(C=O)C.C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([NH:29][CH2:28][CH2:27][NH:26][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH:12]=[N:11][C:10]=1[N+:16]([O-:18])=[O:17]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

7

反応物 3

HCID 81531DiisopropylethylamineHCID 187201N-BOC-ethylenediamineHCID 223185103-(2,4-Dichlorophenyl)-5-bromo-2-nitropyrazine

生成物 1

HCID 120860201,1-Dimethylethyl 2-{[6-(2,4-dichlorophenyl)-5-nitropyrazin-2-yl]amino}ethylcarbamate

試薬・触媒・溶媒 3

HCID 962Water溶媒
HCID 6228
Dimethylformamide
溶媒
HCID 8857Ethyl Acetate溶媒

反応条件

温度
80 °C

実験手順

To a solution of 3-(2,4-dichlorophenyl)-5-bromo-2-nitropyrazine (1.4 g, 4.0 mmol) in DMF (10 ml) were added Boc-ethylenediamine (960 mg, 6.0 mmol) and DIPEA (1.5 ml). The solution was stirred overnight at 80° C. The solution was cooled to room temperature, taken in ethyl acetate and water. The layers were separated and the organic layer was washed with water and brine, dried, concentrated and purified to afford the title product.

後処理

  1. temperatureThe solution was cooled to room temperature
  2. customThe layers were separated
  3. washthe organic layer was washed with water and brine
  4. customdried
  5. concentrationconcentrated
  6. custompurified

出典と根拠

ORDレコード
ord-b61889c5d39c48bdb21ed41d49f74ecf
出典データセット
uspto-grants-2003_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06608063B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート