1-Benzyl-3-ethyl-4-hydroxypiperidine → 3-Ethylpiperidin-4-ol
反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH:10]([CH2:15][CH3:16])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[Pd+2].[OH-]>[CH2:15]([CH:10]1[CH:11]([OH:14])[CH2:12][CH2:13][NH:8][CH2:9]1)[CH3:16]参加物
5
実験手順
A mixture of 1-benzyl-3-ethyl-4-hydroxypiperidine (5.0 g, 22.0 mmole) and palladium hydroxide (1.5 g) in methanol (100 ml) was stirred at 5.0 g, 22.0 mmole) and palladium hydroxide (1.5 g) in methanol (100 ml) was stirred at 50-55° C. in hydrogen atmosphere (1 atm.) for 20 hr. The catalyst was filtered off, washed with methanol, and filtrate was concentrated to dryness to give 3-ethyl-4-hydroxypiperidine as oil. Yield 2.9 g (94%), C7H15NO, m/z 130 (M+1).
後処理
- filtrationThe catalyst was filtered off
- washwashed with methanol, and filtrate
- concentrationwas concentrated to dryness
出典と根拠
- ORDレコード
- ord-8eda4e99072d423ca3f7f36185454433
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06608078B2
反応ノート
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