HCID 23003721、化合物 → 4-Hydroxy-3-methyl-4-trifluoromethyl-piperidine
反応式
C([N:8]1[CH2:13][CH2:12][C:11]([OH:18])([C:14]([F:17])([F:16])[F:15])[CH:10]([CH3:19])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[Pd+2].[OH-]>[OH:18][C:11]1([C:14]([F:17])([F:15])[F:16])[CH2:12][CH2:13][NH:8][CH2:9][CH:10]1[CH3:19]参加物
5
実験手順
A mixture of 1-benzyl-4-hydroxy-3-methyl-4-trifluoromethylpiperidine (5.1 g, 18.68 mmole) and 20% palladium hydroxide (1 g) in methanol (100 ml) was stirred in hydrogen atmosphere (1 atm.) for 12 hr at 35° C. Catalyst was filtered off, washed with methanol, filtrate was concentrated to dryness to give 4-hydroxy-3-methyl-4-trifluoromethyl-piperidine as oil. Yield 3.4 g (99%), C7H12F3NO, m/z 184 (M+1)
後処理
- filtrationCatalyst was filtered off
- washwashed with methanol, filtrate
- concentrationwas concentrated to dryness
出典と根拠
- ORDレコード
- ord-a734d4632f7642b4873f33c4afed0799
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06608078B2
反応ノート
読み込み中…