1-Benzyl-3,5-dimethyl-3-ethyl-4-hydroxypiperidine → 3,5-Dimethyl-3-ethyl-4-hydroxypiperidine
反応式
C([N:8]1[CH2:13][CH:12]([CH3:14])[CH:11]([OH:15])[C:10]([CH3:18])([CH2:16][CH3:17])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[Pd+2].[OH-]>[CH3:18][C:10]1([CH2:16][CH3:17])[CH:11]([OH:15])[CH:12]([CH3:14])[CH2:13][NH:8][CH2:9]1参加物
5
実験手順
A mixture of 1-benzyl-3,5-dimethyl-3-ethyl-4-hydroxypiperidine (2.9 g, 11.74 mmole) and 20% palladium hydroxide (0.5 g) in methanol (20 ml) was stirred in hydrogen atmosphere (1 atm.) for 8 hr at 35° C. Catalyst was filtered off, washed with methanol, filtrate was concentrated to dryness to give 3,5-dimethyl-3-ethyl-4-hydroxypiperidine as oil. Yield 1.7 g (93%), C9H19NO, m/z 158 (M+1).
後処理
- filtrationCatalyst was filtered off
- washwashed with methanol, filtrate
- concentrationwas concentrated to dryness
出典と根拠
- ORDレコード
- ord-ab6dfa7b91e8455d9e544d86e4d60c23
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06608078B2
反応ノート
読み込み中…