Sodium borohydride → HCID 23003647、化合物

HRID 396338ノート

反応式

HRID 396338 の反応式
[BH4-].[Na+].[CH2:3]([N:10]1[CH2:15][CH:14]([CH2:16][CH3:17])[C:13](=[O:18])[C:12]([CH2:20][CH3:21])([CH3:19])[CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[CH2:3]([N:10]1[CH2:15][CH:14]([CH2:16][CH3:17])[CH:13]([OH:18])[C:12]([CH2:20][CH3:21])([CH3:19])[CH2:11]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 222788783,5-Diethyl-3-methyl-1-(phenylmethyl)-4-piperidinone

生成物 1

HCID 23003647HCID 23003647、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium borohydride (0.18 g, 4.8 mmole) was added to the stirred solution of 1-benzyl-3,5-diethyl-3-methylpiperidin-4-one (2.0 g, 7.72 mmole) in methanol (20 ml) at 0-5° C. over a period of 5 min, and stirring was continued for 1 hr at ambient temperature. The reaction mixture was concentrated to dryness, triturated with water (20 ml) and extracted with ethyl acetate. The ethyl acetate extract was dried (Na2SO4) and concentrated to dryness to furnish 1-benzyl-3,5-diethyl-4-hydroxy-3-methylpiperidine as oil. Yield 1.8 g (89%), C17H27NO, m/z 262 (M+l).

後処理

  1. concentrationThe reaction mixture was concentrated to dryness
  2. customtriturated with water (20 ml)
  3. extractionextracted with ethyl acetate
  4. extractionThe ethyl acetate extract
  5. dry with materialwas dried (Na2SO4)
  6. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-c82c1ff15c98495c9ae641759fe7f02d
出典データセット
uspto-grants-2003_08
特許番号
US06608078B2

反応ノート

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