Water → Ethyl 4-azidobutanoate

HRID 396684ノート

反応式

HRID 396684 の反応式
Br[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[N-:10]=[N+:11]=[N-:12].[Na+].O>CO>[N:10]([CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])=[N+:11]=[N-:12]

参加物

5

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 76300Ethyl 4-bromobutyrate

生成物 1

HCID 12382175Ethyl 4-azidobutanoate収率 98.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of ethyl 4-bromobutyrate (10.0 g, 51.3 mmol), NaN3 (6.66 g, 102 mmol) and 25 ml of water in 75 ml of MeOH was refluxed for 3.5 hrs. The MeOH was removed in vacuo and residue was partitioned between CHCl3 (200 ml) and water (50 ml). The organic layer was separated and washed with water. After drying and evaporation of solvent, ethyl 4-azidobutyrate (7.94 g, 98.6%) was obtained as a colorless oil.

後処理

  1. customThe MeOH was removed in vacuo and residue
  2. customwas partitioned between CHCl3 (200 ml) and water (50 ml)
  3. customThe organic layer was separated
  4. washwashed with water
  5. customAfter drying
  6. customevaporation of solvent

出典と根拠

ORDレコード
ord-92b6b338837d48d2a25bc7d004562592
出典データセット
uspto-grants-2003_08
特許番号
US06608086B2

反応ノート

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