Trifluoroacetic acid → (Pyrole-2-carbonyl)-N-(benzyl)glycine

HRID 396869ノート

反応式

HRID 396869 の反応式
C([O:5][C:6](=[O:23])[CH2:7][N:8]([C:16]([C:18]1[NH:19][CH:20]=[CH:21][CH:22]=1)=[O:17])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[NH:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[C:16]([N:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:7][C:6]([OH:23])=[O:5])=[O:17]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acid2 回HCID 70020108(Pyrrole-2-carbonyl)-N-(benzyl)glycine-t-butyl ester

生成物 1

HCID 18762404(Pyrole-2-carbonyl)-N-(benzyl)glycine収率 94.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution containing 2.85 g (9.01 mmol) of (Pyrrole-2-carbonyl)-N-(benzyl)glycine-t-butyl ester in 50 mL of anhydrous dichloromethane cooled to 0° C. was added 25 mL of TFA dropwise. After 90 minutes an additional 25 mL of TFA was added and allowed to stir for 30 minutes. The mixture was evaporated in vacuo to afford 2.19 g of (Pyrole-2-carbonyl)-N-(benzyl)glycine as a tan solid. FAB MS [M+H] m/z; Calcd. 259, Found 259.

後処理

  1. customThe mixture was evaporated in vacuo

出典と根拠

ORDレコード
ord-9ed06d8471ec4d13beac60ac094fb64b
出典データセット
uspto-grants-2003_08
特許番号
US06608175B2

反応ノート

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