Hexane → 1-(4-Bromophenyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride

HRID 397052ノート

反応式

HRID 397052 の反応式
[Br:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:22].CCCCCC>C(Cl)(Cl)Cl>[ClH:22].[Br:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=3)[CH2:10][CH2:9][N:8]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 8058HexaneHCID 24819Phosphorus pentachlorideHCID 110241034-bromo-N-[2-(3-methoxyphenyl)ethyl]benzamide

生成物 1

HCID 181724611-(4-Bromophenyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride収率 69%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of 4-bromo-N-[2-(3-methoxyphenyl)ethyl]benzamide (5.00 g, 15.0 mmol) in CHCl3 (30 ml) was added phosphorous pentachloride (5.30 g, 25.0 mmol) and the mixture stirred for 18 hr at rt under N2. Hexane was added to the mixture and the liquid was then decanted off. EtOH (15 ml) was added to the residue and the mixture was triturated with diethyl ether to give 3.65 g (69% yield) of off-white solid.

後処理

  1. customthe liquid was then decanted off
  2. additionEtOH (15 ml) was added to the residue
  3. customthe mixture was triturated with diethyl ether

出典と根拠

ORDレコード
ord-1ac3f707267e41fa8e00cbe33e0b9d5b
出典データセット
uspto-grants-2003_08
特許番号
US06608203B2

反応ノート

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