Water → Methyl 2-(methylamino)-2-phenylacetate

HRID 3974

反応式

HRID 3974 の反応式
Br[CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[Cl-].[CH3:14][NH3+:15].C(=O)(O)[O-].[Na+].O>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl>[CH3:14][NH:15][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4]

参加物

7

反応物 4

HCID 962WaterHCID 11637Methanamine, hydrochloride (1:1)HCID 137806Benzeneacetic acid, alpha-bromo-, methyl esterHCID 516892Sodium Bicarbonate

生成物 1

HCID 13852358Methyl 2-(methylamino)-2-phenylacetate収率 71.2%

試薬・触媒・溶媒 2

HCID 66133Benzyl triethylammonium chloride触媒HCID 6344Dichloromethane溶媒

実験手順

In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.

後処理

  1. temperatureto refluxed
  2. temperaturerefluxed for about 18 hours
  3. temperatureThe mixture was then cooled
  4. washwashed three times with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated by vacuum evaporation

出典と根拠

ORDレコード
ord-c156814239954cc794d18661347d1e7d
出典データセット
uspto-grants-1988_02
特許番号
US04723031

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