Water → Methyl 2-(methylamino)-2-phenylacetate
反応式
Br[CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[Cl-].[CH3:14][NH3+:15].C(=O)(O)[O-].[Na+].O>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl>[CH3:14][NH:15][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4]参加物
7
実験手順
In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.
後処理
- temperatureto refluxed
- temperaturerefluxed for about 18 hours
- temperatureThe mixture was then cooled
- washwashed three times with water
- dry with materialdried over magnesium sulfate
- concentrationconcentrated by vacuum evaporation
出典と根拠
- ORDレコード
- ord-c156814239954cc794d18661347d1e7d
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04723031
反応ノート
読み込み中…
