Water → 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine

HRID 397400

反応式

HRID 397400 の反応式
C(=O)([O-])[O-].[Cs+].[Cs+].[CH3:7]I.[Cl:9][C:10]1[C:11]2[CH:18]=[CH:17][NH:16][C:12]=2[N:13]=[CH:14][N:15]=1.O>CN(C=O)C>[Cl:9][C:10]1[C:11]2[CH:18]=[CH:17][N:16]([CH3:7])[C:12]=2[N:13]=[CH:14][N:15]=1

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-

生成物 1

HCID 2658294-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine収率 88%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

According to Scheme 5, cesium carbonate (968 mg, 3 mmol) followed by methyl iodide (1 g, 7.1 mmol) was added to a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (121 mg, 0.79 mmol) in DMF (5 mL). The mixture was stirred at room temperature for 6 hours. The reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried, concentrated and column chromatographed to give 116 mg (88%) of 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine as a white solid. 1H NMR (360 MHz, DMSO-d6) 8.62 (s, 1H), 7.71 (s, 1H), 6.62 (s, 1H), 3.84 (s, 3H, CH3).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated
  5. customcolumn chromatographed

出典と根拠

ORDレコード
ord-a110dd028d084fa8af55e563f9c61804
出典データセット
uspto-grants-2003_08
特許番号
US06610688B2

関連ノート

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