Water → 2-[1,2,3]Thiadiazol-4-yl-benzylamine

HRID 397498ノート

反応式

HRID 397498 の反応式
[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[N:12]=[N:13][S:14][CH:15]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>O1CCCC1>[S:14]1[CH:15]=[C:11]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH2:4][NH2:1])[N:12]=[N:13]1

参加物

5

反応物 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 218662814-(2-Azidomethyl-phenyl)-[1,2,3]thiadiazole

生成物 1

HCID 114012722-[1,2,3]Thiadiazol-4-yl-benzylamine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4-(2-azidomethyl-phenyl)-[1,2,3]thiadiazole (1.0 g, 4.6 mmol), triphenylphosphine (1.4 g, 5.5 mmol) and water (0.12 ml, 6.9 mmol) in tetrahydrofuran (20 ml) was stirred at room temperature overnight. Solvent evaporation and flash chromatography (silica gel, chloroform-2-propanol, 95:5-92:8) gave 2-[1,2,3]thiadiazole-4-yl-benzylamine; 1H NMR (CDCl3, 300 MHz) δ8.87 (s, 1H), 7.67 (d, 1H, J=8 Hz), 7.45 (m, 3H), 3.88 (s, 2H).

後処理

  1. customSolvent evaporation and flash chromatography (silica gel, chloroform-2-propanol, 95:5-92:8)

出典と根拠

ORDレコード
ord-6f2b996dda2942d4b2c01d1a5c9c0b6f
出典データセット
uspto-grants-2003_08
特許番号
US06610701B2

反応ノート

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