3-(Tetrazol-1-yl)cyanopyridine → 3-(Tetrazol-1-yl)-2-aminomethylpyridine
反応式
[N:1]1([C:6]2[C:7]([C:12]#[N:13])=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:5]=[N:4][N:3]=[N:2]1>[Pd].C(O)C>[N:1]1([C:6]2[C:7]([CH2:12][NH2:13])=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:5]=[N:4][N:3]=[N:2]1参加物
4
実験手順
A solution of 3-(tetrazol-1-yl)cyanopyridine (250 mg, 1.45 mmol) and 45% by weight of palladium on carbon, 10% catalyst (110 mg) in ethanol (75 ml) was placed on a PARR Hydrogenation Apparatus under a hydrogen atmosphere at 55 psi. overnight. The mixture was filtered through celite and concentrated to give 3-(tetrazol-1-yl)-2-aminomethylpyridine; 1H NMR (CD3OD) δ9.60 (s, 1H), 8.83-8.81 (m, 1H), 7.99-7.97 (m, 1H), 7.59-7.56 (m, 1H), 3.77 (s, 2H).
後処理
- customovernight
- filtrationThe mixture was filtered through celite and
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-788c7a8e25a44e5bab14c54fc3c0f9f9
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610701B2
反応ノート
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