5-Chloronaproxen, (S)- → Naproxen

HRID 3976

反応式

HRID 3976 の反応式
Cl[C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C@H:14]([CH3:18])[C:15]([OH:17])=[O:16])=[CH:7]2>[OH-].[Na+].[Al].[Ni]>[CH3:13][O:12][C:11]1[CH:2]=[C:3]2[C:8](=[CH:9][CH:10]=1)[CH:7]=[C:6]([C@H:14]([CH3:18])[C:15]([OH:17])=[O:16])[CH:5]=[CH:4]2

参加物

4

反応物 1

HCID 130752095-Chloronaproxen, (S)-

生成物 1

HCID 156391Naproxen

試薬・触媒・溶媒 2

HCID 6336846Nickel aluminide触媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of 1 g of (S)-2-(5-chloro-6-methoxy-2-naphthyl)-propionic acid in 20 ml of 10% aqueous sodium hydroxide solution at 90° C. is treated with 3 g of a nickel-aluminum alloy in small portions. After stirring the mixture for two hours, it is filtered, diluted with excess dilute hydrochloric acid and extracted with methylene chloride. The organic phase is evaporated to dryness and the residue recrystallized from methylene chloride/hexane to yield (S)-2-(6-methoxy-2-naphthyl)propionic acid after recrystallization.

後処理

  1. filtrationit is filtered
  2. additiondiluted with excess dilute hydrochloric acid
  3. extractionextracted with methylene chloride
  4. customThe organic phase is evaporated to dryness
  5. customthe residue recrystallized from methylene chloride/hexane

出典と根拠

ORDレコード
ord-0089af8057e946a18b16755f3f9439f0
出典データセット
uspto-grants-1988_02
特許番号
US04723033

関連ノート

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