6-Methoxy-alpha-tetralone → 6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

6-Methoxytetralone (10 g, 0.057 mol) was mixed with 150 ml of dry ethanol and sodium borohydride (1.2 eq) was added by portions to the stirred mixture. The reaction mixture was left to stir at ambient temperature for 15 h. The reaction mixture was then concentrated by rotary evaporation, mixed with 100 ml of water and heated for 1 h at 45° C.. The resulting mixture was extracted into diethyl ether (3×80 ml). Combined organic extract was dried over Na2SO4 and concentrated by rotary evaporation to give 10.39 g of yellow oil which was used in the next step without additional purification.

1. additionwas added by portions to the stirred mixture
2. waitThe reaction mixture was left
3. concentrationThe reaction mixture was then concentrated by rotary evaporation
4. additionmixed with 100 ml of water
5. temperatureheated for 1 h at 45° C.
6. extractionThe resulting mixture was extracted into diethyl ether (3×80 ml)
7. extractionCombined organic extract
8. dry with materialwas dried over Na2SO4
9. concentrationconcentrated by rotary evaporation

ORDレコード

ord-f4f2892c0c89430e9e765dc353fd6adc

出典データセット

uspto-grants-2003_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06610714B2