Oxalyl chloride → HCID 57035411、化合物

反応式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:15][CH2:14][CH2:13][C@H:12]2[C:16]([NH2:18])=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(Cl)(=O)C(Cl)=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]2[CH2:15][CH2:14][CH2:13][C@H:12]2[C:16]#[N:18])(=[O:10])=[O:9])=[CH:6][CH:7]=1

参加物

反応物 2

HCID 65578Oxalyl chloride

HCID 975442HCID 975442、化合物

生成物 1

HCID 57035411HCID 57035411、化合物

実験手順

The title compound was prepared by a similar method to Preparation 3 from (2S)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarboxamide [see Preparation 50] and oxalyl chloride. The crude product was purified by column chromatography on silica gel eluting with dichloromethane to afford (2S)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarbonitrile as a white solid.

後処理

customThe crude product was purified by column chromatography on silica gel eluting with dichloromethane

出典と根拠

ORDレコード: ord-d8441bc1a298499bb6a89aefc59a963e
出典データセット: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06610707B1

反応ノート

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