Sodium Hydroxide → Naproxen Sodium

HRID 3977

反応式

HRID 3977 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2.[OH-].[Na+:19]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([O-:16])=[O:15])[CH:7]=[CH:6]2.[Na+:19]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 156391Naproxen

生成物 1

HCID 23681059Naproxen Sodium

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)-propionic acid in 5 ml of methanol is added a 1 molar equivalent of sodium hydroxide, in the form of a 0.1N solution. The solvent is evaporated in vacuo and the residue is taken up in 2 ml of methanol, followed by precipitation with ether, to yield crude sodium (S)-2-(6-methoxy-2-naphthyl)propionate.

後処理

  1. customThe solvent is evaporated in vacuo
  2. customfollowed by precipitation with ether

出典と根拠

ORDレコード
ord-969a0003bb064226bfa65a3513e9c62c
出典データセット
uspto-grants-1988_02
特許番号
US04723033

関連ノート

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