Sodium Iodide → (3-Iodopropyl)cyclopentane
反応式
BrC1C=CC(S(O[CH2:12][CH2:13][CH2:14][CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)(=O)=O)=CC=1.[I-:20].[Na+]>CC(C)=O>[CH:15]1([CH2:14][CH2:13][CH2:12][I:20])[CH2:19][CH2:18][CH2:17][CH2:16]1参加物
4
実験手順
To a solution of 3-cyclopentylpropyl 4-bromobenzenesulfonate (Preparation 12, 1.0 g, 2.85 mmol) in acetone (30 ml) was added sodium iodide (1.0 g, 6.67 mmol) and the reaction mixture was left to stir at room temperature for 16 h. The resulting precipitate was filtered and the filtrate was diluted with water (100 ml) and extracted with dichloromethane (100 ml). The extract was washed with brine (100 ml), dried (MgSO4) and concentrated in vacuo to give the title compound as a light pink oil (0.60 g, 90%).
後処理
- waitthe reaction mixture was left
- filtrationThe resulting precipitate was filtered
- additionthe filtrate was diluted with water (100 ml)
- extractionextracted with dichloromethane (100 ml)
- washThe extract was washed with brine (100 ml)
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-a4a4b46a21084b6fbd2895328fa0a516
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610711B2
反応ノート
読み込み中…