Sodium Iodide → 4-(2-Iodoethyl)-1,1-dimethylcyclohexane
反応式
BrC1C=CC(S(O[CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][C:17]([CH3:21])([CH3:20])[CH2:16][CH2:15]2)(=O)=O)=CC=1.[I-:22].[Na+]>CC(C)=O>[I:22][CH2:12][CH2:13][CH:14]1[CH2:19][CH2:18][C:17]([CH3:21])([CH3:20])[CH2:16][CH2:15]1参加物
4
実験手順
To a solution of 2-(4,4-dimethylcyclohexyl)ethyl 4-bromobenzenesulfonate (Preparation 16, 410 mg, 1 mmol) in acetone (100 ml) was added sodium iodide (370 mg, 2.5 mmol), and the mixture was heated under reflux for 3 h. After allowing the reaction mixture to cool to room temperature, the mixture was filtered and the filtrate was diluted with water (500 ml) and extracted with diethyl ether (500 ml). The organic extract was dried (MgSO4), filtered and concentrated in vacuo to afford the title compound as a colourless oil (220 mg, 83%).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 3 h
- filtrationthe mixture was filtered
- additionthe filtrate was diluted with water (500 ml)
- extractionextracted with diethyl ether (500 ml)
- extractionThe organic extract
- dry with materialwas dried (MgSO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-325b46b2db94438d98754737fb9390a0
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610711B2
反応ノート
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