N-Ethyl-1,2,3,6-tetrahydro-4-(3-(1-methylethoxy)phenyl)pyridine → N-Ethyl-4-(3-(1-methylethoxy)phenyl)piperidine

HRID 397738ノート

反応式

HRID 397738 の反応式
[CH2:1]([N:3]1[CH2:8][CH:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH:16]([CH3:18])[CH3:17])[CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]>C(O)C.[Pd]>[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH:16]([CH3:17])[CH3:18])[CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

参加物

4

反応物 1

HCID 22707935N-Ethyl-1,2,3,6-tetrahydro-4-(3-(1-methylethoxy)phenyl)pyridine

生成物 1

HCID 23001057N-Ethyl-4-(3-(1-methylethoxy)phenyl)piperidine収率 99.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

N-Ethyl-1,2,3,6-tetrahydro-4-(3-(1-methylethoxy)phenyl)pyridine (Preparation 44, 2.0 g, 8.16 mmol) was dissolved in ethanol (20 ml) and 5% palladium on carbon (0.2 g) was added. The suspension was heated at 60° C. under hydrogen (20 psi) for 5 h. The mixture was cooled and the solid was removed by filtration through Arbocel™, washing the resultant cake with ethyl acetate. The filtrate was concentrated in vacuo to give the title compound as an oil (2.0 g, 99%) which was used without further purification.

後処理

  1. temperatureThe mixture was cooled
  2. customthe solid was removed by filtration through Arbocel™
  3. washwashing the resultant cake with ethyl acetate
  4. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-a7bd88c9793b452192f3e6a0804da337
出典データセット
uspto-grants-2003_08
特許番号
US06610711B2

反応ノート

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