Hydrochloric Acid → isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2.Cl>C(O)C(C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([O:16][CH2:4][CH:5]([CH3:10])[CH3:6])=[O:15])[CH:7]=[CH:6]2参加物
4
実験手順
A solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)propionic acid in 5 ml of isobutyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue is purified by chromatography using an alumina substrate to yield isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate.
後処理
- distillationthe excess alcohol is distilled off in vacuo
- customthe residue is purified by chromatography
出典と根拠
- ORDレコード
- ord-8b2fe1a99b9b4f7d9bf65ad29d804e7a
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04723033
反応ノート
読み込み中…