Hydrochloric Acid → isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate

HRID 3978

反応式

HRID 3978 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2.Cl>C(O)C(C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([O:16][CH2:4][CH:5]([CH3:10])[CH3:6])=[O:15])[CH:7]=[CH:6]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 156391Naproxen

生成物 1

HCID 54469957isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate

試薬・触媒・溶媒 1

HCID 6560Isobutanol溶媒

実験手順

A solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)propionic acid in 5 ml of isobutyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue is purified by chromatography using an alumina substrate to yield isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate.

後処理

  1. distillationthe excess alcohol is distilled off in vacuo
  2. customthe residue is purified by chromatography

出典と根拠

ORDレコード
ord-8b2fe1a99b9b4f7d9bf65ad29d804e7a
出典データセット
uspto-grants-1988_02
特許番号
US04723033

関連ノート

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