N-bromobutanimide → HCID 15895947、化合物
反応式
[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([C:12]#[N:13])[O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C1C(=O)N([Br:21])C(=O)C1>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[F:1][C:2]1[C:11]2[O:10][CH2:9][C:8]([Br:21])([C:12]#[N:13])[O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 70 °C
実験手順
A solution containing 6.44 g of the nitrile obtained in Stage 2 (36 mmol), 6.40 g of NBS (36 mmol, 1 eq.), and 100 mg of benzoyl peroxide in 200 ml of CCl4 is heated at 70° C. for 48 hours. The mixture is allowed to cool to room temperature. The reaction mixture is then filtered. The solid is washed with CCl4 and the mother liquors are evaporated to dryness. 9.3 g of an orange-yellow oil are isolated (quantitative yield).
後処理
- temperatureto cool to room temperature
- filtrationThe reaction mixture is then filtered
- washThe solid is washed with CCl4
- customthe mother liquors are evaporated to dryness
出典と根拠
- ORDレコード
- ord-9a90c428121445fb8387f17aa25f2f9f
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610725B1
反応ノート
読み込み中…