Acetic Acid → 1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

HRID 397922ノート

反応式

HRID 397922 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[CH:9](OCC)(OCC)OCC.[N+:19]([CH2:22]C(OCC)=O)([O-])=O.[C:28]([OH:31])(=[O:30])[CH3:29]>[Fe]>[Br:1][C:2]1[CH:3]=[C:4]([N:5]2[CH:9]=[C:29]([C:28]([OH:31])=[O:30])[N:19]=[CH:22]2)[CH:6]=[CH:7][CH:8]=1

参加物

6

反応物 4

HCID 176Acetic Acid2 回HCID 115623-BromoanilineHCID 31214Ethyl orthoformate2 回HCID 69379Ethyl nitroacetate

生成物 1

HCID 234449541-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 23925Iron触媒

実験手順

Following the general method described in example 234, 3-bromoaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp. 205-207° C. (H2O/dioxane), MS: m/e=267 (M−H−).

出典と根拠

ORDレコード
ord-0adcc3ee905e4f5495fbea9c23ee5369
出典データセット
uspto-grants-2003_08
特許番号
US06610723B2

反応ノート

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