Acetic Acid → 1-(5-Chloro-pyridin-2-yl)-1H-imidazole-4-carboxylic Acid Ethyl Ester
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[CH:9]([O:16][CH2:17][CH3:18])([O:13]CC)OCC.[N+:19]([CH2:22][C:23](OCC)=O)([O-])=O.[C:28](O)(=O)C>[Fe]>[CH2:17]([O:16][C:9]([C:22]1[N:19]=[CH:28][N:1]([C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=2)[CH:23]=1)=[O:13])[CH3:18]参加物
6
実験手順
Following the general method described in example 384, 2-amino-5-chloropyridine was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid. After workup and chromatography the title compound was obtained as a beige crystalline solid. Mp. 163-164° C. (AcOEt), MS: m/e=252 (M+H+).
出典と根拠
- ORDレコード
- ord-782f3ba2bde242fe9941911d915a2432
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610723B2
反応ノート
読み込み中…