Iodine chloride → 8Iodo-2,2,4,4-tetramethy-6-chromanoic Acid

HRID 398058ノート

反応式

HRID 398058 の反応式
[CH3:1][C:2]1([CH3:17])[CH2:11][C:10]([CH3:13])([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:14]([OH:16])=[O:15])[CH:8]=2)[O:3]1.[I:18]Cl.BrC1C=C(C(O)=O)C=C2C=1OC(C)(C)CC2(C)C>CC(O)=O>[I:18][C:5]1[CH:6]=[C:7]([C:14]([OH:16])=[O:15])[CH:8]=[C:9]2[C:4]=1[O:3][C:2]([CH3:17])([CH3:1])[CH2:11][C:10]2([CH3:12])[CH3:13]

参加物

5

反応物 3

HCID 24640Iodine chlorideHCID 157287092,2,4,4-Tetramethyl-3,4-dihydro-2H-1-benzopyran-6-carboxylic acidHCID 158405358-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid2 回

生成物 1

HCID 230017638Iodo-2,2,4,4-tetramethy-6-chromanoic Acid収率 106.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 2,2,4,4-tetramethyl-6-chromanoic acid (66 mg, 0.28 mmol) in 0.8 ml of AcOH was added ICl (0.07 ml, 1.4 mmol). The resulting colored solution was stirred at room temperature for overnight. Following the same procedure as for the synthesis of 8-bromo-2,2,4,4-tetramethyl-6-chromanoic acid (Compound P), the reaction gave the title compound (107 mg) as white solids.

出典と根拠

ORDレコード
ord-4373544e45264bb59b9adcb73541a31d
出典データセット
uspto-grants-2003_08
特許番号
US06610744B2

反応ノート

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