Hydrochloric Acid → Midodrine Hydrochloride

HRID 398267ノート

反応式

HRID 398267 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([O:17][CH3:18])=[C:7]([CH:9]([OH:16])[CH2:10][NH:11][C:12]([CH2:14][NH2:15])=[O:13])[CH:8]=1.C(O)C.[ClH:22]>C(O)(C)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([O:17][CH3:18])=[C:7]([CH:9]([OH:16])[CH2:10][NH:11][C:12]([CH2:14][NH2:15])=[O:13])[CH:8]=1.[ClH:22]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 4195Midodrine

生成物 1

HCID 18340Midodrine Hydrochloride収率 96%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

The reaction vessel is charged with 5.0 g Midodrine base and 60 ml ethanol. The mixture is heated to reflux to obtain a clear solution. To the hot mixture is added 6.3 ml of a 22% solution of hydrochloric acid in isopropanol in portions. During the addition, the Midodrine HCl will crystallize from solution. After cooling to 5°-10° C., the product is filtered to afford 4.8 g (96% yield) of Midodrine HCl (m.p.: 200.8°-201.8° C.).

後処理

  1. temperatureThe mixture is heated
  2. temperatureto reflux
  3. customto obtain a clear solution
  4. additionDuring the addition
  5. customthe Midodrine HCl will crystallize from solution
  6. temperatureAfter cooling to 5°-10° C.
  7. filtrationthe product is filtered

出典と根拠

ORDレコード
ord-efea40f5122d455ba810835027575e1e
出典データセット
uspto-grants-2003_08
特許番号
US06610886B2

反応ノート

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