基本情報
- CAS
3092-17-9- 標準SMILES
COc1ccc(OC)c(C(O)CNC(=O)CN)c1.Cl- InChIKey
MGCQZNBCJBRZDT-UHFFFAOYSA-N- 分子式
- C12H19ClN2O4
- 平均分子量
- 290.74 g/mol
- 単同位体質量
- 290.1033348
概要
Midodrine hydrochloride is a hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as a sympathomimetic agent, an alpha-adrenergic agonist and a vasoconstrictor agent. It contains a midodrine(1+).
名称と識別子
- 優先名称
- Midodrine Hydrochloride
- IUPAC
- 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide;hydrochloride
- 現地名
- ミドドリン
- 英語名
- Midodrine hydrochloride
- 分子式
- C12H19ClN2O4
- 分子量
- 290.74
名称と別名
MIDODRINE HYDROCHLORIDE43218-56-0Midodrine HCLPro-AmatineProAmatineHipertanAmatineOrvatenGutronMidamineSt. Peter 224(+-)-Midodrine hydrochloride
名称をさらに表示
ミドドリン 塩酸塩ミドドリン塩酸塩 (JAN)ミドドリン塩酸塩MIDODRINEST-1085Prestwick_625
MetligineMidodrine MonohydrochlorideA-4020 LinzDTXSID104749359JV96YTXVST-PETER-224NSC-758429ST1085 HYDROCHLORIDE
データベース識別子
- CAS
3092-17-9、43218-56-0- PubChem CID
- 18340
- DTXSID
DTXSID1047493- ChEMBL
CHEMBL1200461- ChEBI
CHEBI:31847- UNII
- 59JV96YTXV
- EC Number
- 256-148-3、622-590-4
物性
構造計算による物性
- 極性表面積
- 93.8 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 5
- 回転可能結合数
- 6
- 重原子数
- 19
- 形式電荷
- 0
- 複雑度
- 262
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section154 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
物理化学的性質
- 融点
- 192 · 192-193°C
- 貯蔵温度
- -20 °C · -20°C Freezer
- 主な用途
- 法医学と毒物学医薬品（低分子化合物）獣医
- InChI
- InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
- InChIKey
- MGCQZNBCJBRZDT-UHFFFAOYSA-N
- SMILES
- C1(C(O)CNC(=O)CN)C=C(C=CC=1OC)OC.Cl
- CAS データベース
- 3092 · 3092-17-9(CAS DataBase Reference)
化学的性質
化学的特性Crystalline Solid
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory.
Danger
H301 (66.7%): Toxic if swallowed [Danger Acute toxicity, oral]
危険有害性情報
Hazard Classes and Categories
Acute Tox. 3 (66.7%)
Acute Tox. 3 (97.6%)
毒性情報
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Midodrine hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
安全データ
- wgk
- 3
- rtecs
- AB4343000
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 29242990
- risk_code
- 25
- hazard_code
- T
- safety_code
- 45
- Hazard Classifications
- Acute Tox. 3 Oral
- ストレージクラス
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
化学と産業
薬理情報
FDA Pharmacological Classification
MIDODRINE HYDROCHLORIDE
alpha-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]
MeSH Pharmacological Classification
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs used to cause constriction of the blood vessels.
Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS.
応用分野
用途選択的α1 受容体刺激作用を 示します。
用途選択的α1 受容体刺激作用を 示します。
使用A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects
一般的な説明Midodrine is the N-glycyl prodrug ofthe selectiveα1-agonist desglymidodrine. Removal of theN-glycyl moiety from midodrine occurs readily in the liver aswell as throughout the body, presumably by amidases.Midodrine is orally active and represents another example ofa dimethoxy-β-phenylethylamine derivative that is used therapeuticallyfor its vasoconstrictor properties. Specifically, it isused in the treatment of symptomatic orthostatic hypotension.
上流・下流製品情報
上流原料
サプライヤー64 社
北京华美互利生物化工010-56205725 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
Hebei Zhuanglai Chemical Trading Co Ltd+86-16264648883 · [email protected]
成都奥邦药业有限公司18980796919 · [email protected]
四川奥邦医药贸易有限公司+86-28-+86-28-87843998-6060-6060 +86-18980796919 · [email protected]
重庆康洲智通医药科技有限公司173-08362167 17308362167 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
南京世洲生物科技有限公司025-025-85560043 17301488900 · [email protected]
Aladdin Scientific[email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
Syntechem Co.,Ltd[email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.—
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
Protheragen-ING+86-15618352007 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
上海喀露蓝科技有限公司18149758185 18149758185 · [email protected]
陕西缔都医药化工有限公司+86-029-81138252 +86-173 9270 1263 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
深圳利斯康医药科技有限公司0755-89396905 · [email protected]
陕西缔都医药化工有限公司+86-29-87569262 +86-15003564040 · [email protected]
成都奥邦药业有限公司18980796919; 18980796919 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
湖北恒绿源科技有限公司027-88188016 18717196322 · [email protected]
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上海氟瑞化学科技有限公司021-52230662 13795399395 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
湖北威德利化学试剂有限公司15871722230 · [email protected]
成都标样生物科技有限公司028-81700200 13308200041 · [email protected]
南京罗迈美生物科技有限公司[email protected]
湖北威德利化学试剂有限公司17771478861 13419635609 · [email protected]
武汉魔力生物科技有限公司18872289958、027-52304252、3400508168 · [email protected]
武汉中瑞希康化学制品有限公司15623071665 · [email protected]
爱必信（上海）生物科技有限公司13761418683 · [email protected]
武汉研哲科技有限公司15527250409 · [email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
武汉峰耀同辉化学制品有限公司027-87466105 15377573527 · [email protected]
厦门盈融达化工有限公司+86-0592-6210733 · [email protected]
湖北康鑫源顺医药化工有限公司027-51831887 15337167856 · [email protected]
上海凯裕医药科技有限公司17317130613 · [email protected]
career henan chemical co+86-0371-86658258 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
深圳天缘医药科技有限公司+86-755-23284190 13684996853 · [email protected]
深圳利斯康医药科技有限公司+86-755-89396905 +86-15013857715 · [email protected]
湖北星城生物科技有限公司19171210221 · [email protected]
海蔚化学86-21-51086038 · [email protected]
深圳市创鑫生物科技有限公司13417589054 · [email protected]
補足説明
定義ChEBI: A hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a periph ral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
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