Hydrochloric Acid → HCID 23000268、化合物
反応式
[C:1]([C:3]1[C:4]([CH3:12])=[C:5]2[C:9](=[N:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2)#[N:2].[ClH:13]>[Pd].CO>[ClH:13].[ClH:13].[NH2:2][CH2:1][C:3]1[C:4]([CH3:12])=[C:5]2[C:9](=[N:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2参加物
5
実験手順
A suspension of 5-cyano-4-methyl-7-azaindole (48 mg, 0.31 mmol) and 10% palladium on carbon (25 mg) in methanol (10 mL) and concentrated HCl (0.5 mL) was shaken on a Parr apparatus under hydrogen (50 psi) for 6 h. The mixture was filtered through celite and evaporated in vacuo. The residue was dissolved in a minimum volume of methanol, ether was added and the solids collected by filtration to give the title compound as a pale yellow solid:
後処理
- filtrationThe mixture was filtered through celite
- customevaporated in vacuo
- dissolutionThe residue was dissolved in a minimum volume of methanol, ether
- additionwas added
- filtrationthe solids collected by filtration
出典と根拠
- ORDレコード
- ord-7028770566d54bfeaa225807ee369b91
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610692B1
反応ノート
読み込み中…