Dichloromethane → 1H-Indazole-5-carbonitrile

HRID 398355ノート

反応式

HRID 398355 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6](F)=[C:7]([CH:10]=1)[CH:8]=O)#[N:2].C(Cl)Cl.O.[NH2:16][NH2:17]>>[C:1]([C:3]1[CH:10]=[C:7]2[C:6](=[CH:5][CH:4]=1)[NH:17][N:16]=[CH:8]2)#[N:2]

参加物

4

反応物 3

HCID 6344DichloromethaneHCID 24654Hydrazine hydrate (1:1)HCID 109097255-Cyano-2-fluorobenzaldehyde

生成物 1

HCID 111263841H-Indazole-5-carbonitrile

実験手順

5-Cyano-2-fluorobenzaldehyde (512 mg, 3.43 mmol) was dissolved in hydrazine hydrate (25 mL) at room temperature and the solution left to stand overnight. To this reaction mixture was added methylene chloride (30 mL). The mixture was purified by filtration through a pad of silica eluting with methylene chloride, concentrated in vacuo to afford a white solid:

後処理

  1. waitthe solution left
  2. filtrationThe mixture was purified by filtration through a pad of silica eluting with methylene chloride
  3. concentrationconcentrated in vacuo
  4. customto afford a white solid

出典と根拠

ORDレコード
ord-af8254012b4749e383f127b9a2eb1307
出典データセット
uspto-grants-2003_08
特許番号
US06610692B1

反応ノート

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