trans-3-Cyclopropylmethoxy-4-azidotetrahydrofuran → trans-3-Cyclopropylmethoxy-4-aminotetrahydrofuran
反応式
[CH:1]1([CH2:4][O:5][C@H:6]2[C@H:10]([N:11]=[N+]=[N-])[CH2:9][O:8][CH2:7]2)[CH2:3][CH2:2]1>CCOC(C)=O.[Pd]>[CH:1]1([CH2:4][O:5][C@H:6]2[C@H:10]([NH2:11])[CH2:9][O:8][CH2:7]2)[CH2:2][CH2:3]1参加物
4
実験手順
A solution of trans-3-cyclopropylmethoxy-4-azidotetrahydrofuran from step 3 above (1.2 g, mmol, 6.55 mmol) and 10% Pd on carbon (150 mg) in EtOAc (35 mL) was stirred under an atmosphere of hydrogen at ambient pressure and ambient temperature for 6 h. The catalyst was removed by filtration and the filtrate solvents were removed in vacuo to give the title compound as an oil (1.1 g, TLC Rf=0.3, 95:5:0.25 CH2Cl2:MeOH:NH4OH).
後処理
- customThe catalyst was removed by filtration
- customthe filtrate solvents were removed in vacuo
出典と根拠
- ORDレコード
- ord-85099aea01ea450ea620184891a84ca8
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610692B1
反応ノート
読み込み中…