Water → 2-Amino-2-ethylhexan-1-ol
反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[NH2:7][C:8]([CH2:18][CH3:19])([CH2:14][CH2:15][CH2:16][CH3:17])[C:9](OCC)=[O:10].[OH-].[Na+].O>C(OCC)C>[NH2:7][C:8]([CH2:18][CH3:19])([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][OH:10]参加物
6
実験手順
Lithium aluminium hydride (22.2 g) was added to anhydrous diethyl ether (450 ml) under nitrogen. The product from (d) (129.0 g) was diluted with diethyl ether (40 ml) and added dropwise. The reaction was refluxed for 1 hour then cooled to room temperature. 1M sodium hydroxide (23 ml) was added dropwise followed by deionised water. The resulting suspension was filtered and the filtrate concentrated to give the desired product as a colourless oil (87.9 g). 1H NMR consistent with the proposed structure.
後処理
- additionadded dropwise
- temperatureThe reaction was refluxed for 1 hour
- filtrationThe resulting suspension was filtered
- concentrationthe filtrate concentrated
出典と根拠
- ORDレコード
- ord-440518ac96714560be561b9d2444286a
- 出典データセット
- uspto-grants-1998_10
- 特許番号
- US05817652
反応ノート
読み込み中…