Tetrahydrofuran → Methyl 4'-[[2-butyl-4-quinolinyl]-methyl]1,1'-biphenyl-2-carboxylate

反応式

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH2:12][CH2:13][CH2:14][CH3:15])[CH:3]=1.[Br-].[CH3:17][O:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[CH:32]=[CH:31][C:30]([Zn]C)=[CH:29][CH:28]=1)=[O:20].O1CCC[CH2:36]1>[Zn]>[CH2:12]([C:4]1[CH:3]=[C:2]([CH2:36][C:30]2[CH:31]=[CH:32][C:27]([C:22]3[C:21]([C:19]([O:18][CH3:17])=[O:20])=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:28][CH:29]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)[CH2:13][CH2:14][CH3:15]

参加物

実験手順

Using the procedure of Step G of Example 1, 500 mg of 2-butyl-4-chloro quinoline of Step D were introduced into a previously prepared solution of 475 mg of electrolytic zinc, 275 mg of tetrakistriphenyl-phosphine palladium and 2.075 g of [[2'-(methoxycarbonyl)(1,1'-biphenyl)-4-yl]-methyl zinc bromide prepared as in Example 1 in 13 ml of tetrahydrofuran. After chromatographing on silica (eluant:choloroform-hexane-ethyl acetate 100-100-10), 621 mg of the expected product were obtained.