Iodine → HCID 12786936、化合物

HRID 399143ノート

反応式

HRID 399143 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[N:5]=1)(=[O:3])[CH3:2].[I:11]I>N1C=CC=CC=1>[I-:11].[Br:10][C:6]1[N:5]=[C:4]([C:1](=[O:3])[CH2:2][N+:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:4]=2)[CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 807IodineHCID 112985782-Acetyl-6-bromopyridine

生成物 1

HCID 12786936HCID 12786936、化合物収率 167.9%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 2-acetyl-6-bromopyridine (0.075 mol), 25 ml of pyridine, and iodine (0.075 mol) was allowed to react at 100° C. for 45 minutes and then cooled to room temperature. The reaction mixture was filtered, the solid product was triturated with CH2Cl2 (200 ml), isolated by filtration, and the residual solvent was removed under vacuum to yield 25.5 g (85%) of the desired salt. Melting point: 176°-178° C.

後処理

  1. customto react at 100° C. for 45 minutes
  2. filtrationThe reaction mixture was filtered
  3. customthe solid product was triturated with CH2Cl2 (200 ml)
  4. customisolated by filtration
  5. customthe residual solvent was removed under vacuum

出典と根拠

ORDレコード
ord-a776590251bf4765b63bab6d99fdbaaf
出典データセット
uspto-grants-1998_10
特許番号
US05817774

反応ノート

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