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(Chlorothio)formyl chloride → Ethyl 2-hydroxy-4-methyl-1,3-thiazole-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (Chlorothio)formyl chloride | HCID 75990 | — |
| 反応物 | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Ethyl 2-hydroxy-4-methyl-1,3-thiazole-5-carboxylate | HCID 11074139 | 62.4% |
反応手順
25 g of chlorocarbonylsulphenyl chloride was added dropwise to 25 g of ethyl 3-aminocrotonate in 300 ml of toluene while being cooled with ice. The solution was heat-refluxed for 2 hours, and then cooled. The crystals precipitated were collected through filtration, and then washed twice with toluene to obtain 22.3 g of 4-methyl-5-ethoxycarbonyl-2-thiazolone as purple crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05817829 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-6ed8cb3f17d5497897d310ce6f90b851 |
| 出典メモ | uspto-grants-1998_10 |