反应详情

25 g of chlorocarbonylsulphenyl chloride was added dropwise to 25 g of ethyl 3-aminocrotonate in 300 ml of toluene while being cooled with ice. The solution was heat-refluxed for 2 hours, and then cooled. The crystals precipitated were collected through filtration, and then washed twice with toluene to obtain 22.3 g of 4-methyl-5-ethoxycarbonyl-2-thiazolone as purple crystals.

1. temperaturewhile being cooled with ice
2. temperatureThe solution was heat-refluxed for 2 hours
3. temperaturecooled
4. customThe crystals precipitated
5. filtrationwere collected through filtration
6. washwashed twice with toluene