Thionyl Chloride → 3-Chloro-1-methyl-1h-pyrazole-5-carbonyl chloride

HRID 399191

反応式

HRID 399191 の反応式
[Cl:1][C:2]1[CH:6]=[C:5]([C:7](O)=[O:8])[N:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C1C=CC=CC=1>[Cl:1][C:2]1[CH:6]=[C:5]([C:7]([Cl:13])=[O:8])[N:4]([CH3:10])[N:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 189704593-chloro-1-methyl-1H-pyrazole-5-carboxylic acid

生成物 1

HCID 189704623-Chloro-1-methyl-1h-pyrazole-5-carbonyl chloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

100 g of 3-chloro-1-methyl-5-pyrazole-carboxylic acid (the Compound No. 4.1 (a) of the present invention) were suspended in 200 ml of benzene, and 150 ml of thionyl chloride were added thereto dropwise. Then, the mixture was heat-refluxed for 4 hours. The reaction mixture was allowed to cool, and the solvent was then distilled off under reduced pressure. The resulting residue was distilled under reduced pressure to obtain 103 g of the intended 3-chloro-1-methyl-5-pyrazolecarbonyl chloride.

後処理

  1. temperatureThen, the mixture was heat-refluxed for 4 hours
  2. temperatureto cool
  3. distillationthe solvent was then distilled off under reduced pressure
  4. distillationThe resulting residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-14124bb4c18a40d087add9a7a5ae0295
出典データセット
uspto-grants-1998_10
特許番号
US05817829

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